Jacques HM Cohen 23 11 23

Comme la vie est brève, il faut en avoir plusieurs à la fois.

Voici sous ma casquette scientifique, le coming-out de plus de 3 ans de travail, avec le résultat fructueux d’un nouvel adjuvant vaccinal, renouvelant en mieux une solution presque centenaire.

Des progrès donc dans le « pré-print » au bout du lien de ChemRxiv. Et encore, on ne vous dit pas tout !! D’autres applications de notre matériau sont en développement. Keep Tuned !!

Leçon importante, c’est un abord mixte entre chimistes des matériaux et immunologistes qui nous a permis d’aboutir, alors que nos cultures et nos langages sont très différents. Il faut parler aux gens dont on ne partage pas la culture !

Although used for one century in billions of people as the vaccine adjuvant with the best benefit/side-effect balance, aluminium salts/gels have drawbacks of rapid leakage of antigens from the injection site and indefinite persistence. Herein, we propose an alternative to canonical Al-adjuvant. Proteins, nucleic acids, and bacteria were successfully encapsulated within an Al-based Metal-Organic Framework (MOF), namely Al-fumarate, using a synthesis process in water and room temperature, compatible with bio-entities preservation. Mice immunizations demonstrated antigenicity preservation of tetanus toxoid and inactivated E. coli, and a stronger adjuvant effect of Al-fumarate than benchmark Al-adjuvant (Alhydrogel) with an initial slow antigen release and a protective effect. The Al-fumarate vaccine formulation was fully resorbable in vivo, disappearing from the injection site, was not exhibiting any toxicity, and was stable for two years. The limitation of Al adjuvants as eliciting only antibody responses was also overcome by co-immobilisation of CpG 1018 with tetanus toxoid.

Résumé graphique.

Fighting against Vaccine Hesitancy:

Since Ramon and Glenny one century ago, Aluminum salts have been used in billions of individuals as the best cost/efficiency adjuvant for long lasting, protective antibody based vaccines. Vaccine hesitancy about that adjuvant is taking concern on the indefinite persistence in the body of injected Aluminum.